Design and synthesis of pyrazole/isoxazole linked arylcinnamides as tubulin polymerization inhibitors and potential antiproliferative agents

As pyrazole and isoxazole based derivatives are well-known for displaying a considerable biological profile, an attempt has been made to unravel their cytotoxic potential. In this context, a number of pyrazole/isoxazole linked arylcinnamide conjugates (15a-o and 21a-n) have been synthesized by emplo...

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Veröffentlicht in:	Organic & biomolecular chemistry 2015-10, Vol.13 (40), p.10162-10178
Hauptverfasser:	Kamal, Ahmed, Shaik, Anver Basha, Rao, Bala Bhaskara, Khan, Irfan, Bharath Kumar, G, Jain, Nishant
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cinnamates - chemistry Cinnamates - pharmacology Dose-Response Relationship, Drug Drug Design Drug Screening Assays, Antitumor HeLa Cells Humans Isoxazoles - chemistry Isoxazoles - pharmacology Molecular Structure Polymerization - drug effects Pyrazoles - chemistry Pyrazoles - pharmacology Structure-Activity Relationship Tubulin - metabolism Tubulin Modulators - chemical synthesis Tubulin Modulators - chemistry Tubulin Modulators - pharmacology
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