Analytical toxicology of fluorinated inhalation anaesthetics

The chemical and pharmacological properties of the current fluorinated inhalation anaesthetics, halothane, enflurane, isoflurane, sevoflurane and desflurane, are surveyed with implications to toxicity. Analytical methods, especially gas chromatography with head space, purge and trap, or pulse heatin...

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Veröffentlicht in:	Forensic science international 1998-11, Vol.97 (2), p.117-133
Hauptverfasser:	Pihlainen, Katja, Ojanperä, Ilkka
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical methods Anesthesia Anesthetics Anesthetics, Inhalation - adverse effects Anesthetics, Inhalation - metabolism Anesthetics, Inhalation - toxicity Animals Biological and medical sciences Chromatography, Gas Drug overdose Extraction Fatalities Fluorides Fluorination Forensic Medicine - methods Gas chromatography General pharmacology Halothane Hepatitis Humans Hydrocarbons, Fluorinated - adverse effects Hydrocarbons, Fluorinated - metabolism Hydrocarbons, Fluorinated - toxicity Inhalation Inhalation anaesthetic Isoflurane Lipids Liver Medical sciences Metabolism Metabolites Molecular weight Mortality Narcotics Nitrous oxide Patients Pediatrics Pharmacology. Drug treatments Proteins Pulse heating Respiration Sevoflurane Toxicity Toxicology
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Beschreibung
Zusammenfassung:	The chemical and pharmacological properties of the current fluorinated inhalation anaesthetics, halothane, enflurane, isoflurane, sevoflurane and desflurane, are surveyed with implications to toxicity. Analytical methods, especially gas chromatography with head space, purge and trap, or pulse heating extraction, are reviewed in forensic toxicological and occupational/therapeutic monitoring contexts.
ISSN:	0379-0738 1872-6283
DOI:	10.1016/S0379-0738(98)00148-0