Mouse centromere protein F (Cenpf) gene maps to the distal region of Chromosome 1 by interspecific backcross analysis
Human centromere binding protein F (CENPF) is a 367-kDa nuclear matrix-associated chromosome passenger. The protein is uniformly distributed in the cell nucleus during S phase, localizes onto the kinetochore from late G sub(2)/M to metaphase, relocates onto the spindle equator and intracellular brid...
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Veröffentlicht in: | Cytogenetic and genome research 1998-01, Vol.82 (3-4), p.180-181 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Human centromere binding protein F (CENPF) is a 367-kDa nuclear matrix-associated chromosome passenger. The protein is uniformly distributed in the cell nucleus during S phase, localizes onto the kinetochore from late G sub(2)/M to metaphase, relocates onto the spindle equator and intracellular bridge during late anaphase and cleavage furrow formation and then is degraded following completion of mitosis. CENPF has been shown to be a valuable proliferation marker for various human tumours and has been mapped to human chromosome 1q32 arrow right q41. Here we report the use of a mouse genomic fragment to map the chromosome position of mouse Cenpf. |
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ISSN: | 1424-8581 0301-0171 1424-859X |
DOI: | 10.1159/000015094 |