Evaluation of unscheduled DNA synthesis (UDS) and replicative DNA synthesis (RDS) following treatment of rats and mice with p-dichlorobenzene

Evaluation of unscheduled DNA synthesis (UDS) and replicative DNA synthesis (RDS) following treatment of rats and mice with p-dichlorobenzene

p‐Dichlorobenzene (PDCB) has been reported to produce tumors in the male and female mouse liver and in the male rat kidney in 2‐year gavage studies (NPT, 1987). To elucidate the possible mechanisms of carcinogenicity more fully, UDS and RDS were evaluated in B6C3F1 mouse hepatocytes and F‐344 rat ki...

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Veröffentlicht in:Teratogenesis, carcinogenesis, and mutagenesis carcinogenesis, and mutagenesis, 1998, Vol.18 (6), p.309-318
Hauptverfasser: Sherman, James H., Nair, Rashmi S., Steinmetz, Karen L., Mirsalis, Jon C., Nestmann, Earle R., Barter, James A.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Carcinogenicity Tests
Cell Division - drug effects
Cells, Cultured
Chemical and industrial products toxicology. Toxic occupational diseases
Chlorobenzenes - administration & dosage
Chlorobenzenes - metabolism
Chlorobenzenes - toxicity
DNA - biosynthesis
DNA Repair
Female
in vivo/in vitro RDS assay
in vivo/in vitro UDS assay
inducer of cell proliferation
Insecticides - toxicity
Kidney - drug effects
Liver - drug effects
Male
Medical sciences
Mice
mouse hepatocytes
Mutagenicity Tests
rat kidney cells
Rats
Rats, Inbred F344
Toxicology
Various organic compounds
α2μ-globulin
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Zusammenfassung:p‐Dichlorobenzene (PDCB) has been reported to produce tumors in the male and female mouse liver and in the male rat kidney in 2‐year gavage studies (NPT, 1987). To elucidate the possible mechanisms of carcinogenicity more fully, UDS and RDS were evaluated in B6C3F1 mouse hepatocytes and F‐344 rat kidney cells by autoradiography following in vivo administration of PDCB. All corn oil gavage doses of PDCB (300, 600, and 1,000 mg/kg) and the negative control resulted in
ISSN:0270-3211
1520-6866
DOI:10.1002/(SICI)1520-6866(1998)18:6<309::AID-TCM5>3.0.CO;2-P