Preoperative biomarkers of tumour vascularity are elevated in patients with glioblastoma multiforme

Highlights • We investigated the utility of cellular (circulating endothelial cell [CEC] and progenitor cell [CEP]) and imaging (perfusion MRI) biomarkers in patients with glioblastoma multiforme (GBM). • A novel perfusion MRI parameter (rCBVload ) was developed to estimate the total volume of perfu...

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Veröffentlicht in:	Journal of clinical neuroscience 2015-11, Vol.22 (11), p.1802-1808
Hauptverfasser:	Bennett, Iwan E, Guo, Hui, Kountouri, Nicole, D’abaco, Giovanna M, Hovens, Christopher M, Moffat, Bradford A, Desmond, Patricia, Drummond, Katharine, Kaye, Andrew H, Morokoff, Andrew P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Angiogenesis Inhibitors - therapeutic use Biomarker Biomarkers, Tumor - blood Brain Neoplasms - blood Brain Neoplasms - blood supply Brain Neoplasms - diagnostic imaging Brain Neoplasms - drug therapy Brain Neoplasms - surgery Circulating endothelial cells Disease Progression Endothelial Cells - pathology Female Glioblastoma - blood Glioblastoma - blood supply Glioblastoma - diagnostic imaging Glioblastoma - drug therapy Glioblastoma - surgery Glioblastoma multiforme Humans Magnetic Resonance Angiography Male Middle Aged Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - blood supply Neoplasm Recurrence, Local - diagnostic imaging Neoplasm Recurrence, Local - drug therapy Neoplastic Stem Cells - pathology Neurology Perfusion MRI Predictive Value of Tests Preoperative Period Prognosis Radiography Relative cerebral blood volume
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Zusammenfassung:	Highlights • We investigated the utility of cellular (circulating endothelial cell [CEC] and progenitor cell [CEP]) and imaging (perfusion MRI) biomarkers in patients with glioblastoma multiforme (GBM). • A novel perfusion MRI parameter (rCBVload ) was developed to estimate the total volume of perfused tumour vessels. • CECs were shown to be increased in the presence of GBM. • CEP levels were found to be proportional to tumour vascularity as measured by perfusion MRI.
ISSN:	0967-5868 1532-2653
DOI:	10.1016/j.jocn.2015.06.013