Understanding paediatric allergic fungal sinusitis: Is it more aggressive?

Abstract Objective To study and characterize the features of AFRS in children as compared to adults. Methods 50 consecutive patients of AFRS attending our outpatient department were included in the study from July 2011 to December 2013. They were divided into two groups (A and B) according to age be...

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Veröffentlicht in:International journal of pediatric otorhinolaryngology 2015-11, Vol.79 (11), p.1876-1880
Hauptverfasser: Patro, Sourabha K, Verma, Roshan K, Panda, Naresh K, Chakrabarti, Arunaloke
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Sprache:eng
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Zusammenfassung:Abstract Objective To study and characterize the features of AFRS in children as compared to adults. Methods 50 consecutive patients of AFRS attending our outpatient department were included in the study from July 2011 to December 2013. They were divided into two groups (A and B) according to age being ≤14 years and >14 years. Clinical history and examination included anterior rhinoscopy, SNOT 20 scores, CT of Nose and PNS (para nasal sinuses) (Lund Mackay scores), diagnostic nasal endoscopy (Kupferberg's grades), punch biopsy from nasal polyp, serum IgE, absolute eosinophil counts (AEC) and Aspergillus skin hypersensitivity test was done in all patients for conformation of AFRS. Bent and Kuhn's criteria were used for diagnosis. Sweat chloride levels were done in all patients of group A. Results Group A had 12 patients and group B had 38. Mean duration of symptoms was significantly less in children as compared to adults ( p < 0.05). All patients of both groups had nasal polyposis at presentation. Unilateral disease and multisinus involvement was more common in children (6/12) as compared to adults. Proptosis (2/12) and telecanthus (4/12) was more common in children (group A) as compared to adults (group B). LM (Lund Mackay) scores and serum IgE were significantly high in children as compared to adults. Follow up CT scans showed early evidence of recurrence in children as compared to adults ( p < 0.05). Conclusion AFRS was seen to be more aggressive in children with increased fungal load when compared with adults. Typically, AFRS in children was less responsive to treatment with increased recurrence rates.
ISSN:0165-5876
1872-8464
DOI:10.1016/j.ijporl.2015.08.032