Auto-fluorescent mesoporous ZnO nanospheres for drug delivery carrier application

The zinc oxide (ZnO) nanostructures are very interesting materials because of their practical bio-applications in various areas such as drug delivery, construction of biomaterial, optical and acoustic devices as well as their bactericidal properties. Herein, we have prepared spheroidal mesoporous auto-fluorescent ZnO nanospheres by modified continuous distillation method, showed a blue emission in the concentration of 2mg/ml at 444nm. The auto-fluorescent property of ZnO nanospheres can be used in biomaterials for target sites of tissues/cells, thereby enabling site drug delivery especially in cancer therapy. Initially, the auto-fluorescent property of the ZnO material was characterized by different techniques like PXRD, FESEM with EDAX graph, TEM, ICP-OES, particle sizes, zeta potentials and BET analysis. The mesoporous ZnO nanospheres has attracted well for their crystalline, functionalized and intensified fluorescent properties. The surface of the ZnO nanospheres was porous, spherical and nanometric in size. The synthesized material has enormous potential as a nano-drug-carrier. Preliminary studies indicated that the material prepared has an excellent scope for detection and delivery at the site of therapeutic action. Graphical explanation of mesoporous ZnO nanospheres with auto-fluorescence property plots was examined on a small piece of rat skin surface, photographic image of 1 to 5mg/ml and single particle of mesoporous auto-fluorescent ZnO nanospheres. [Display omitted] •New biomaterial approach for pharmaceutical use of autofluorescent ZnO nanosphere.•Autofluorescent ZnO nanosphere as bionanocarrier for detection & delivery of drug.•Acceptable amount of Zn2+ and nanosized particles of mesoporous ZnO nanospheres.•ZnO mesosphere carrier as bioessential metal in cellular system.•Drug loaded ZnO nanospheres as tolerable dose in biological systems.