Copper-catalyzed oxidative C-H/C-H cross-coupling of benzamides and thiophenes

Copper-catalyzed oxidative C-H/C-H cross-coupling of benzamides and thiophenes

A copper-catalyzed oxidative C-H/C-H cross-coupling of benzamides and thiophenes has been developed. This reaction exhibits a broad substrate scope and excellent tolerance of functional groups. The directing group could be readily removed to afford 2-thienylbenzoic acids.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-08, Vol.51 (64), p.12823-12826
Hauptverfasser: Zhao, Sheng, Yuan, Jun, Li, Yi-Chen, Shi, Bing-Feng
Format: Artikel
Sprache:eng
Schlagworte:
Benzamide
Benzamides - chemistry
Carbon - chemistry
Catalysis
Copper - chemistry
Functional groups
Hydrogen - chemistry
Oxidation-Reduction
Thiophenes
Thiophenes - chemistry
Tolerances
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Beschreibung
Zusammenfassung:A copper-catalyzed oxidative C-H/C-H cross-coupling of benzamides and thiophenes has been developed. This reaction exhibits a broad substrate scope and excellent tolerance of functional groups. The directing group could be readily removed to afford 2-thienylbenzoic acids.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05058h