Palladium-catalysed decarboxylative nitrile insertion via C-H activation or self-coupling of indole-2-carboxylic acids: a new route to indolocarbolines and triindoles

Palladium catalysed-reaction of indole carboxylic acids with nitriles in the presence of Ag2CO3 proceeds via decarboxylative dual C-H activation leading to the nitrile insertion products, triazaindeno-fluorenes (indolocarbolines); in the absence of nitrile, diindolocarbazoles (heptacyclic triindoles...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-08, Vol.51 (60), p.12008-12011
Hauptverfasser:	Prasad Tulichala, R N, Kumara Swamy, K C
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Carboxylic acids Indoles Insertion Nitriles Palladium
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Palladium catalysed-reaction of indole carboxylic acids with nitriles in the presence of Ag2CO3 proceeds via decarboxylative dual C-H activation leading to the nitrile insertion products, triazaindeno-fluorenes (indolocarbolines); in the absence of nitrile, diindolocarbazoles (heptacyclic triindoles or triazatruxenes) are formed.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c5cc03160e