MiR-143 and miR-135 inhibitors treatment induces skeletal myogenic differentiation of human adult dental pulp stem cells

Highlights • Human adult DPSCs were induced to myogenic differentiation by 5-Aza. • Expression of miR-135 and miR-143 was decreased in myoblast DPSCs induced by 5-Aza. • Anti-miR-135 and anti -miR-143 transfection induced myogenic differentiation of DPSCs.

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Bibliographische Detailangaben
Veröffentlicht in:	Archives of oral biology 2015-11, Vol.60 (11), p.1613-1617
Hauptverfasser:	Li, Dongxia, Deng, Tianzheng, Li, Hongshi, Li, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult Stem Cells - cytology Adult Stem Cells - drug effects Adult Stem Cells - physiology Advanced Basic Science Antisense oligonucleotide inhibitor Azacitidine - analogs & derivatives Azacitidine - pharmacology Cell Differentiation - drug effects Cell Differentiation - genetics Cells, Cultured Dental Pulp - cytology Dental Pulp - drug effects Dental Pulp - metabolism Dental pulp stem cell Dentistry Humans MicroRNAs - antagonists & inhibitors MicroRNAs - biosynthesis MicroRNAs - genetics miR-135 miR-143 Molar, Third - cytology Molar, Third - drug effects Muscle Development - drug effects Muscle Development - genetics Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Myoblasts - cytology Myoblasts - physiology Myogenic differentiation Oligonucleotides, Antisense - administration & dosage Oligonucleotides, Antisense - genetics Transfection Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Human adult DPSCs were induced to myogenic differentiation by 5-Aza. • Expression of miR-135 and miR-143 was decreased in myoblast DPSCs induced by 5-Aza. • Anti-miR-135 and anti -miR-143 transfection induced myogenic differentiation of DPSCs.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2015.08.010