Integrated CLL Scoring System, a New and Simple Index to Predict Time to Treatment and Overall Survival in Patients With Chronic Lymphocytic Leukemia

Micro-Abstract In a series of 608 patients with chronic lymphocytic leukemia (CLL), we identified the best biologic prognostic markers (fluorescence in-situ hybridization analysis, IGHV mutational status, and CD38 expression), and in a cohort of 212 subjects, we combined them in a new and easy scori...

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Veröffentlicht in:	Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2015-10, Vol.15 (10), p.612-620.e5
Hauptverfasser:	Visentin, Andrea, Facco, Monica, Frezzato, Federica, Castelli, Monica, Trimarco, Valentina, Martini, Veronica, Gattazzo, Cristina, Severin, Filippo, Chiodin, Giorgia, Martines, Annalisa, Bonaldi, Laura, Gianesello, Ilaria, Pagnin, Elisa, Boscaro, Elisa, Piazza, Francesco, Zambello, Renato, Semenzato, Gianpietro, Trentin, Livio
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase 1 - genetics ADP-ribosyl Cyclase 1 - metabolism Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism CD38 Chromosomes, Human, Pair 11 - genetics Chromosomes, Human, Pair 13 - genetics DNA Mutational Analysis Female FISH Hematology, Oncology and Palliative Medicine Humans ICSS IGHV Immunoglobulin Heavy Chains - genetics Kaplan-Meier Estimate Leukemia, Lymphocytic, Chronic, B-Cell - mortality Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemia, Lymphocytic, Chronic, B-Cell - therapy Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Middle Aged Multivariate Analysis Prognosis Prognostic models Proportional Hazards Models Severity of Illness Index Time-to-Treatment Treatment Outcome ZAP-70 Protein-Tyrosine Kinase - metabolism
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Zusammenfassung:	Micro-Abstract In a series of 608 patients with chronic lymphocytic leukemia (CLL), we identified the best biologic prognostic markers (fluorescence in-situ hybridization analysis, IGHV mutational status, and CD38 expression), and in a cohort of 212 subjects, we combined them in a new and easy scoring system, the integrated CLL scoring system (ICSS).
ISSN:	2152-2650 2152-2669
DOI:	10.1016/j.clml.2015.06.001