Antimelanogenic Effects of Picrionoside A Isolated from the Leaves of Korean Ginseng

This study was initiated to isolate active metabolites from the leaves of Panax ginseng. Among them, picrionoside A, a megastigmane glucoside, was isolated from the leaves of P. ginseng C. A. MAYER and its chemical structure was determined based on spectroscopic methods, including FAB-MS, one-dimens...

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Veröffentlicht in:Biological & pharmaceutical bulletin 2015/10/01, Vol.38(10), pp.1663-1667
Hauptverfasser: Lee, Dae-Young, Jeong, Sang Chul, Jeong, Yong Tae, Lee, Mi-Kyoung, Seo, Kyeong-Hwa, Lee, Jae-Won, Kim, Geum-Soog, Lee, Seung-Eun, Baek, Nam-In, Kim, Jin Hee
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Sprache:eng
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Zusammenfassung:This study was initiated to isolate active metabolites from the leaves of Panax ginseng. Among them, picrionoside A, a megastigmane glucoside, was isolated from the leaves of P. ginseng C. A. MAYER and its chemical structure was determined based on spectroscopic methods, including FAB-MS, one-dimensional (1D)-NMR, 2D-NMR, and IR spectroscopy. Picrionoside A from P. ginseng has not been investigated previously, and its biological or pharmaceutical activities have not been reported elsewhere. The IC50 value of mushroom tyrosinase-inhibitory activity of picrionoside A was 9.8 µM, and the rate of inhibition of synthesized melanin content in melan-a cells was 17.1% at a concentration of 80 µM without cytotoxicity. Furthermore, picrionoside A dramatically reduced body pigmentation in the zebrafish model. Taken together, the results suggest that picrionoside A isolated from the leaves of P. ginseng may be an effective skin-whitening agent that could be a potent candidate material in the cosmetic industry.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b15-00410