Circulating Levels of Urokinase-Type Plasminogen Activator Receptor and D-Dimer in Patients With Hematological Malignancies

Micro-Abstract In this study we aimed to estimate sera levels of urokinase plasminogen activator receptor (uPAR) and D-dimer (D-D) as fibrinolysis markers and to determine their association with outcome. We found an increased frequency of positive D-D. Highest sera levels of D-D and soluble uPAR wer...

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Veröffentlicht in:	Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2015-10, Vol.15 (10), p.621-626
Hauptverfasser:	Rubio-Jurado, Benjamín, Tello-González, Alejandra, Bustamante-Chávez, Lili, de la Peña, Aurora, Riebeling-Navarro, Carlos, Nava-Zavala, Arnulfo Hernan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological Markers Biomarkers, Tumor - blood Bone Marrow Neoplasms Case-Control Studies Coagulation Cross-Sectional Studies Female Fibrin Fibrinogen Degradation Products - metabolism Hematologic Neoplasms Hematology, Oncology and Palliative Medicine Humans Lymphoma - blood Lymphoma - mortality Lymphoma - therapy Male Middle Aged Receptors, Urokinase Plasminogen Activator - blood Survival Analysis Treatment Outcome uPAR
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Zusammenfassung:	Micro-Abstract In this study we aimed to estimate sera levels of urokinase plasminogen activator receptor (uPAR) and D-dimer (D-D) as fibrinolysis markers and to determine their association with outcome. We found an increased frequency of positive D-D. Highest sera levels of D-D and soluble uPAR were detected for lymphoma patients versus control participants. In our population, these biomarkers were found to be related with treatment response and survival.
ISSN:	2152-2650 2152-2669
DOI:	10.1016/j.clml.2015.07.632