Collision cross sections of high-mannose N-glycans in commonly observed adduct states--identification of gas-phase conformers unique to [M-H](-) ions

Collision cross sections of high-mannose N-glycans in commonly observed adduct states--identification of gas-phase conformers unique to [M-H](-) ions

We report collision cross sections (CCS) of high-mannose N-glycans as [M + Na](+), [M + K](+), [M + H](+), [M + Cl](-), [M + H2PO4](-) and [M - H](-) ions, measured by drift tube (DT) ion mobility-mass spectrometry (IM-MS) in helium and nitrogen gases. Further analysis using traveling wave (TW) IM-M...

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Veröffentlicht in:Analyst (London) 2015-10, Vol.140 (20), p.6799-6803
Hauptverfasser: Struwe, W B, Benesch, J L, Harvey, D J, Pagel, K
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Carbohydrate Conformation
Cattle
Helium - chemistry
Mannose - chemistry
Mass Spectrometry
Nitrogen - chemistry
Polysaccharides - chemistry
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Beschreibung
Zusammenfassung:We report collision cross sections (CCS) of high-mannose N-glycans as [M + Na](+), [M + K](+), [M + H](+), [M + Cl](-), [M + H2PO4](-) and [M - H](-) ions, measured by drift tube (DT) ion mobility-mass spectrometry (IM-MS) in helium and nitrogen gases. Further analysis using traveling wave (TW) IM-MS reveal the existence of distinct conformers exclusive to [M - H](-) ions.
ISSN:0003-2654
1364-5528
DOI:10.1039/c5an01092f