Expression and clinical contribution of MRGD mRNA in non-small cell lung cancers

MAS-related G protein-coupled receptor, member D (MRGD) has been reported to be involved in tumorigenesis in vivo. However, the clinical role of MRGD in non-small cell lung cancer (NSCLC) remains unclarified. The purpose of the current study was to detect the expression of MRGD mRNA in NSCLC formali...

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Veröffentlicht in:	Journal of B.U. ON. 2015-07, Vol.20 (4), p.1101-1106
Hauptverfasser:	Li, Zuyun, Xie, You, Zhong, Tengfei, Zhang, Xiuling, Dang, Yiwu, Gan, Tingqing, Chen, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Female Gene Expression Regulation, Neoplastic Humans Lung Neoplasms - mortality Lung Neoplasms - pathology Male Neoplasm Staging Prognosis Receptors, G-Protein-Coupled - genetics Retrospective Studies RNA, Messenger - analysis
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Zusammenfassung:	MAS-related G protein-coupled receptor, member D (MRGD) has been reported to be involved in tumorigenesis in vivo. However, the clinical role of MRGD in non-small cell lung cancer (NSCLC) remains unclarified. The purpose of the current study was to detect the expression of MRGD mRNA in NSCLC formalin-fixed (FF), paraffin-embedded (PE) tissues and to investigate the clinicopathological significance of the MRGD level in NSCLC patients. The expression of MRGD mRNA was examined in 125 NSCLC tissue samples together with paired para-noncancerous FF/PE tissues by using real time quantitative PCR (qRT-PCR). Furthermore, the relationship between MRGD level and clinicopathological parameters of NSCLC was analyzed. The average level of MRGD in NSCLC tumor tissues (1.0682±0.6096) was remarkably higher than that in the adjacent non-cancerous lung tissue (0.3994±0.2838, p
ISSN:	1107-0625