Mannitol and Outcome in Intracerebral Hemorrhage: Propensity Score and Multivariable Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial 2 Results

BACKGROUND AND PURPOSE—Mannitol is often used to reduce cerebral edema in acute intracerebral hemorrhage but without strong supporting evidence of benefit. We aimed to determine the impact of mannitol on outcome among participants of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhag...

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Veröffentlicht in:	Stroke (1970) 2015-10, Vol.46 (10), p.2762-2767
Hauptverfasser:	Wang, Xia, Arima, Hisatomi, Yang, Jie, Zhang, Shihong, Wu, Guojun, Woodward, Mark, Muñoz-Venturelli, Paula, Lavados, Pablo M, Stapf, Christian, Robinson, Thompson, Heeley, Emma, Delcourt, Candice, Lindley, Richard I, Parsons, Mark, Chalmers, John, Anderson, Craig S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antihypertensive Agents - therapeutic use Blood Pressure - drug effects Brain Edema - drug therapy Brain Edema - etiology Cerebral Hemorrhage - complications Cerebral Hemorrhage - drug therapy Diuretics, Osmotic - therapeutic use Female Humans Hypertension - complications Hypertension - drug therapy Male Mannitol - therapeutic use Middle Aged Propensity Score Treatment Outcome
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Zusammenfassung:	BACKGROUND AND PURPOSE—Mannitol is often used to reduce cerebral edema in acute intracerebral hemorrhage but without strong supporting evidence of benefit. We aimed to determine the impact of mannitol on outcome among participants of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). METHODS—INTERACT2 was an international, open, blinded end point, randomized controlled trial of 2839 patients with spontaneous intracerebral hemorrhage (
ISSN:	0039-2499 1524-4628
DOI:	10.1161/STROKEAHA.115.009357