Lentivirus envelope protein exerts differential neuropathogenic effects depending on the site of expression and target cell

We investigated the neuropathogenic effects of feline immunodeficiency virus (FIV) envelope proteins in the context of both extracellular exposure and intracellular expression in feline neural cells. The envelope from the neurovirulent CSF-derived FIV V1 strain (V1-CSF) conferred infectivity to pseu...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2006-05, Vol.348 (2), p.260-276
Hauptverfasser:	Noorbakhsh, Farshid, Tang, Qing, Liu, Shuhong, Silva, Claudia, van Marle, Guido, Power, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals astrocytes Base Sequence brain Brain - virology cat diseases Cats Cell Line DNA, Viral - genetics endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - virology Endoplasmic reticulum stress Feline immunodeficiency virus Gene Expression Genes, Viral Glia Glycoproteins - genetics Glycoproteins - physiology HeLa Cells Human immunodeficiency virus Humans Immunodeficiency Virus, Feline - classification Immunodeficiency Virus, Feline - genetics Immunodeficiency Virus, Feline - pathogenicity Immunodeficiency Virus, Feline - physiology Indolamine 2,3-dioxygenase interleukin-1 Interleukin-1β Lentivirus Lentivirus Infections - genetics Lentivirus Infections - metabolism Lentivirus Infections - virology Leukocytes, Mononuclear - virology macrophages mononuclear leukocytes neuroglia Neuron Neurons - virology pathogenesis Phylogeny tumor necrosis factor-alpha Tumor necrosis factor-α viral envelope proteins Viral Envelope Proteins - genetics Viral Envelope Proteins - physiology viral proteins Virulence - genetics
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Beschreibung
Zusammenfassung:	We investigated the neuropathogenic effects of feline immunodeficiency virus (FIV) envelope proteins in the context of both extracellular exposure and intracellular expression in feline neural cells. The envelope from the neurovirulent CSF-derived FIV V1 strain (V1-CSF) conferred infectivity to pseudotyped viruses in peripheral blood mononuclear cells ( P
ISSN:	0042-6822 1096-0341
DOI:	10.1016/j.virol.2005.10.044