Metabolic conversion of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD) to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in the male F344/NCr rat

1,1-Dichloro-2,2-bis(p-chlorophenyl)ethane (DDD) and 1,1-dichloro-2, 2-bis(p-chlorophenyl)ethylene (DDE) levels were measured by capillary gas chromatography with electron capture detection in liver and blood serum of male F344/NCr rats exposed for 2 weeks to DDD at dietary concentrations ranging fr...

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Veröffentlicht in:	Archives of environmental contamination and toxicology 1998-07, Vol.35 (1), p.104-108
Hauptverfasser:	Fox, S.D, Roman, J.M, Issaq, H.J, Nims, R.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Feed - analysis Animals Biological and medical sciences Biotransformation BLOOD SERUM Chromatography DDD DDE DDT Dichlorodiphenyl Dichloroethylene - blood Dichlorodiphenyl Dichloroethylene - metabolism Dichlorodiphenyldichloroethane - blood Dichlorodiphenyldichloroethane - pharmacokinetics Diet Drug Administration Schedule Ethane FOIE Gas chromatography Gas Chromatography-Mass Spectrometry HIGADO Insecticides LIVER Liver - metabolism Male Medical sciences METABOLISM METABOLISME METABOLISMO METABOLITE METABOLITES METABOLITOS Nitrous oxide Pesticides, fertilizers and other agrochemicals toxicology RAT RATA RATS Rats, Inbred F344 Rodents SERUM SANGUIN SUERO SANGUINEO TOXICOLOGIA TOXICOLOGIE TOXICOLOGY
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Zusammenfassung:	1,1-Dichloro-2,2-bis(p-chlorophenyl)ethane (DDD) and 1,1-dichloro-2, 2-bis(p-chlorophenyl)ethylene (DDE) levels were measured by capillary gas chromatography with electron capture detection in liver and blood serum of male F344/NCr rats exposed for 2 weeks to DDD at dietary concentrations ranging from 8.51 ppm to 2,000 ppm. DDD burdens in serum ranged from
ISSN:	0090-4341 1432-0703
DOI:	10.1007/s002449900356