Chronic Changes In Serum IL-6 And TNF- alpha Following 12 Weeks Of Concurrent Resistance And Aerobic Exercise Are Dependent On Exercise Mode And May Affect Adaptation

PURPOSE: To examine physiological responses to concurrent resistance and land treadmill training (RT-LTM) compared to concurrent resistance and aquatic treadmill training (RT-ATM) and the chronic effect of each on serum TNF- alpha and IL-6 (cytokines associated with chronic inflammation, CVD, and skeletal muscle metabolism). METHODS: Twenty-six untrained subjects (M: n=13, 98.6+ or -17.1kg, 182.2+ or -6.2cm, 34+ or -11yrs, F: n=13, 78.9+ or -14.0kg, 165.1+ or -5.1cm, 38+ or -11yrs) were screened to assess VO sub(2max), Bcomp (DEXA), and strength (Lifts: leg press, chest press, leg curl, lat pull, leg ext, triceps push-down, biceps curl). Subjects were then randomized into 2 groups (RT-LTM super(m=6, f=7) | RT-ATM super(m=7, f=6)). Each performed progressive RT (2/wk, 3 x 8-12 [at] 60%-->~80% 1RM) for 12 wks. Both groups also performed 12 wks of aerobic LTM or ATM (60-->85%VO sub(2max)) respectively. ATM or LTM occurred immediately following RT sessions and in isolation on a 3 super(rd) day during the wk. Kcal/session: Wk 1-6 = 250-->500 kcal/session, Wk 6-12 = 500 kcal/session. Baseline tests were re-performed at wk 6 and after training. Blood samples were obtained in the rested state before and after training. Serum TNF- alpha and IL-6 was analyzed using a multiplex assay kit (Luminex(R), Millipore(R)). A 2x2 Mixed Model ANOVA w/ repeated measures was used to examine absolute and relative changes in the independent variables listed in the table. RESULTS: (ProQuest: ... denotes formulae and/or non-USASCII text omitted) Values are means + or - SE. % Delta = Individual change from baseline. Like letters = not significantly different between groups, [dagger]=Significant change from baseline ( alpha [< or =] 0.05). CONCLUSION: Chronic RT-LTM and RT-ATM training elicit different effects on markers of chronic inflammation which may be related to differing health and fitness outcomes observed between our groups.