Effects Of The Phosphodiesterase-5 Inhibitor Tadalafil On Parameters Of Aerobic Fitness In Healthy Men

To examine whether 48 h exposure to Tadalafil influences aerobic fitness parameters during graded exercise test (GXT) in healthy men in normoxia. Twelve subjects were randomly assigned to receive either a two consecutive days administration of placebo or Tadalafil (e.g. 20 mg with 36 hours of interval) in a double-blind crossover design, with a 14-days wash-out period between conditions. Compared to placebo, the Tadalafil condition did not influence LT (3.75 + or - 0.41 vs. 3.88 + or - 0.44 mmol/L) and VO sub(2)max (3.46 + or - 0.33 vs. 3.31 + or - 0.28 L/min, respectively for placebo and Tadalafil conditions). Similarly, MPO (285.2 + or - 27.0 vs. 275.0 + or - 25.0 Watts) and TTF (1306.2 + or - 101.8 vs. 1340.0 + or -146.5 s, respectively for placebo and Tadalafil conditions) did not differ between the two conditions.