Predisposing Factors for Spontaneous Closure of Congenital Portosystemic Shunts

In a review of 382 cases of congenital portosystemic shunt, we found that presentation with neonatal cholestasis strongly predicts spontaneous closure of intrahepatic shunts (OR 8.3, 95% CI 3.4-20.2). Spontaneous closure before the 24th month of age is more likely for distal or multiple shunts, but...

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Veröffentlicht in:The Journal of pediatrics 2015-10, Vol.167 (4), p.931-935.e12
Hauptverfasser: Paganelli, Massimiliano, MD, PhD, Lipsich, José E., MD, Sciveres, Marco, MD, Alvarez, Fernando, MD
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Sprache:eng
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Zusammenfassung:In a review of 382 cases of congenital portosystemic shunt, we found that presentation with neonatal cholestasis strongly predicts spontaneous closure of intrahepatic shunts (OR 8.3, 95% CI 3.4-20.2). Spontaneous closure before the 24th month of age is more likely for distal or multiple shunts, but rare for patent ductus venosus.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2015.06.073