Feasibility and safety of enoxaparin whole milligram dosing in premature and term neonates
Objective: The objective of our study was to determine the feasibility and safety of enoxaparin whole milligram dosing in premature and term neonates, and to assess response to treatment. Study Design: Retrospective study of neonates with thrombosis treated between January 2008 and December 2014. Re...
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Veröffentlicht in: | Journal of perinatology 2015-10, Vol.35 (10), p.852-854 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Objective:
The objective of our study was to determine the feasibility and safety of enoxaparin whole milligram dosing in premature and term neonates, and to assess response to treatment.
Study Design:
Retrospective study of neonates with thrombosis treated between January 2008 and December 2014.
Result:
Nineteen premature and 21 term neonates were treated with whole milligram doses of enoxaparin. The mean starting and therapeutic enoxaparin doses were 1.72±0.17 and 1.86±0.17 mg kg
−1
, respectively. Twenty-five (64%) reached therapeutic antifactor Xa (anti-Xa) levels with the starting dose, whereas 14 (36%) required dose adjustments. One neonate reached a supratherapeutic anti-Xa level (>1.0 IU ml
−1
) in the loading phase. No bleeding episodes occurred. The mean treatment duration was 12 weeks. Among 34 (85%) evaluable patients, 23 (68%) had a complete response, 9 (26%) partial and 2 (6%) had a stable thrombotic state.
Conclusion:
Whole milligram dosing of enoxaparin for thrombosis is feasible, safe and effective in premature and term neonates. |
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ISSN: | 0743-8346 1476-5543 |
DOI: | 10.1038/jp.2015.84 |