Changes in the Mother–Placenta–Fetus System Under the Effect of α-Tocopherol in Albino Rats with Normal Pregnancy

The effects of α-tocopherol on the function of the mother–placenta–fetus system and structural changes in the placenta in normal pregnancy were studied in albino rats. The results indicated that inhibition of free radical processes by injections of α-tocopherol in normal pregnancy led to disorders i...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2015-08, Vol.159 (4), p.517-519
Hauptverfasser:	Ivanova, A. S., Peretyatko, L. P., Sitnikova, O. G., Nazarov, S. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Albinism alpha-Tocopherol - pharmacology Animals Animals, Outbred Strains Antioxidants - pharmacology Biomedical and Life Sciences Biomedicine Cell Biology Drug Evaluation, Preclinical Female Fetus - drug effects Internal Medicine Laboratory Medicine Lipid Peroxidation Maternal-Fetal Exchange Nitric Oxide Synthase - metabolism Oxidative Stress Pathology Placenta - drug effects Placenta - enzymology Pregnancy Rats Tocopherols Vascular Endothelial Growth Factor C - metabolism
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Beschreibung
Zusammenfassung:	The effects of α-tocopherol on the function of the mother–placenta–fetus system and structural changes in the placenta in normal pregnancy were studied in albino rats. The results indicated that inhibition of free radical processes by injections of α-tocopherol in normal pregnancy led to disorders in the feto–maternal circulation, which was proven by morphological changes in the placenta. The disorders in the uteroplacental circulation manifested in the development of small-for-date fetuses and erythrocytosis.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-015-3006-6