GnRH-(1–5) activates matrix metallopeptidase-9 to release epidermal growth factor and promote cellular invasion

In the extracellular space, the gonadotropin-releasing hormone (GnRH) is metabolized by the zinc metalloendopeptidase EC3.4.24.15 (EP24.15) to form the pentapeptide, GnRH-(1–5). GnRH-(1–5) diverges in function and mechanism of action from GnRH in the brain and periphery. GnRH-(1–5) acts on the orpha...

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Veröffentlicht in:	Molecular and cellular endocrinology 2015-11, Vol.415, p.114-125
Hauptverfasser:	Cho-Clark, Madelaine, Larco, Darwin O., Zahn, Brian R., Mani, Shaila K., Wu, T. John
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cell invasion Cell Line, Tumor Cell Movement Endometrial Endometrial Neoplasms - metabolism Epidermal Growth Factor - metabolism Epidermal growth factor receptor (EGFR) Female G protein-coupled receptor (GPCR) Gene Expression Regulation, Neoplastic GnRH Gonadotropin-Releasing Hormone - metabolism Humans Matrix metalloproteinase (MMP) Matrix Metalloproteinase 9 - metabolism Neoplasm Metastasis Orphan receptor Peptide Fragments - metabolism Phosphorylation Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Signal Transduction
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