Identification and structure–activity relationships of a new series of Melanocortin-4 receptor antagonists

The identification and optimization of a series of acylguanidine-based melanocortin-4 receptor antagonists is discussed.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-04, Vol.16 (8), p.2302-2305
Hauptverfasser:	Vos, Tricia J., Balani, Suresh, Blackburn, Christopher, Chau, Ryan W., Danca, M. Diana, Drabic, Stacey V., Farrer, Cheryl A., Patane, Michael A., Stroud, Stephen G., Yowe, David L., Claiborne, Christopher F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antagonist Binding Sites Biological and medical sciences Brain - metabolism Guanidine - analogs & derivatives Guanidine - chemistry Guanidine - pharmacology Inhibitory Concentration 50 Medical sciences Melanocortin Mice Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Non-peptide Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Plasma - metabolism Receptor, Melanocortin, Type 4 - antagonists & inhibitors Small molecule Structure-Activity Relationship Sulfhydryl Compounds - chemistry Sulfhydryl Compounds - pharmacology Time Factors
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Beschreibung
Zusammenfassung:	The identification and optimization of a series of acylguanidine-based melanocortin-4 receptor antagonists is discussed.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2006.01.016