Viability assessment of magnetic resonance spectroscopy for the detection of minimal hepatic encephalopathy severity

Highlights • The concentrations of brain metabolites were obtained by LC-model software. • MRS using a 3-T MR scanner could detect cerebral metabolic changes in cirrhotic patients with MHE. • Glu levels were elevated in cirrhotic patients with MHE. • Glu levels could be used as a sensitive indicator...

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Veröffentlicht in:	European journal of radiology 2015-10, Vol.84 (10), p.2019-2023
Hauptverfasser:	Meng, Ling-ping, Chen, Yuan-chang, Li, Yue-hua, Zhu, Jin-shui, Ye, Jian-lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anterior cingulate cortex Aspartic Acid - analogs & derivatives Aspartic Acid - analysis Basal ganglia Basal Ganglia - metabolism Brain - metabolism Cognition - physiology Creatine - analysis Female Glutamic Acid - analysis Glutamine - analysis Gyrus Cinguli - metabolism Hepatic cirrhosis Hepatic Encephalopathy - classification Hepatic Encephalopathy - diagnosis Hepatic Encephalopathy - metabolism Hepatitis - metabolism Humans Inositol - analysis Liver Cirrhosis - diagnosis Liver Cirrhosis - metabolism Liver Cirrhosis, Alcoholic - metabolism Magnetic resonance spectroscopy Magnetic Resonance Spectroscopy - instrumentation Magnetic Resonance Spectroscopy - methods Male Middle Aged Minimal hepatic encephalopathy Neuropsychological Tests Radiology
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Zusammenfassung:	Highlights • The concentrations of brain metabolites were obtained by LC-model software. • MRS using a 3-T MR scanner could detect cerebral metabolic changes in cirrhotic patients with MHE. • Glu levels were elevated in cirrhotic patients with MHE. • Glu levels could be used as a sensitive indicator to evaluate the severity of MHE in patients with cirrhosis.
ISSN:	0720-048X 1872-7727
DOI:	10.1016/j.ejrad.2015.06.027