Non‐steroidal anti‐inflammatory drugs and the risk of head and neck cancer: A case‐control analysis
Non‐steroidal anti‐inflammatory drugs (NSAIDs) and acetylsalicylic acid (aspirin) have been associated with a reduced risk for certain cancers. We explored the association between use of NSAIDs and the risk of head and neck cancer (HNC). We conducted a case‐control analysis in the UK‐based Clinical...
Gespeichert in:
Veröffentlicht in: | International journal of cancer 2015-11, Vol.137 (10), p.2424-2431 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Non‐steroidal anti‐inflammatory drugs (NSAIDs) and acetylsalicylic acid (aspirin) have been associated with a reduced risk for certain cancers. We explored the association between use of NSAIDs and the risk of head and neck cancer (HNC). We conducted a case‐control analysis in the UK‐based Clinical Practice Research Datalink (CPRD) among people below the age of 90 years with incident HNC between 1995 and 2013. Six controls per case were matched on age, sex, calendar time, general practice, and number of years of active history in the CPRD prior to the HNC diagnosis. Other potential confounders including comorbidities and comedication were also evaluated, and we adjusted our final analyses for BMI, smoking and alcohol consumption. Our analyses included 2,745 HNC cases and 16,470 controls. Aspirin or NSAID use overall did not significantly change the HNC risk. However, patients with six or more prescriptions for ibuprofen were at a statistically significantly reduced risk for HNC (adjusted OR 0.59, 95% CI 0.37–0.94). The HNC risk tended to decrease with increasing cumulative exposure to ibuprofen, and to be more pronounced for cancer of the larynx. To conclude, in this large population‐based observational study we found a decreased risk for HNC associated with regular use of ibuprofen.
What's new?
Whether aspirin or non‐steroidal anti‐inflammatory drugs (NSAIDS) can help prevent head and neck cancer (HNC) is unclear. The few epidemiological studies conducted have not convincingly supported or refuted the possibility of a preventative association. The present case‐control analysis attempted to overcome the limitations of those studies by using a large study population and controlling for confounding variables. The results indicate that aspirin and NSAID use have no effect on overall HNC risk. Increasing cumulative exposure specifically to ibuprofen was associated with a significant decrease in HNC risk, suggesting that regular ibuprofen use may be beneficial in HNC prevention. |
---|---|
ISSN: | 0020-7136 1097-0215 |
DOI: | 10.1002/ijc.29601 |