Secular trends and predictors of mortality in acute lymphoblastic leukemia for children of low socioeconomic level in Northeast Brazil

Highlights • We focused our study on the issues faced by clinicians treating children with ALL in the lower socioeconomic areas of Brazil. • We evaluated the results of 35 years of LLA treatment comparing a historical cohort of 25 years to a more recent cohort of 10 years. • Our study highlights tha...

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Veröffentlicht in:	Leukemia research 2015-10, Vol.39 (10), p.1060-1065
Hauptverfasser:	Viana, Simone Santana, de Lima, Leyla Manoella Maurício Rodrigues, do Nascimento, Juliana Brito, Cardoso, Carlos André Ferreira, Rosário, Ana Carolina Dantas, Mendonça, Cristiano de Queiroz, de Menezes-Neto, Osvaldo Alves, Cipolotti, Rosana
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Adolescent Brazil - epidemiology Child Child, Preschool Children Developing Countries Female Hematology, Oncology and Palliative Medicine Humans Infant Infant, Newborn Infection Kaplan-Meier Estimate Low socioeconomic level Male Mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Socioeconomic Factors Young Adult
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Zusammenfassung:	Highlights • We focused our study on the issues faced by clinicians treating children with ALL in the lower socioeconomic areas of Brazil. • We evaluated the results of 35 years of LLA treatment comparing a historical cohort of 25 years to a more recent cohort of 10 years. • Our study highlights that abandonment is not currently a major cause of treatment failure. • We identified that infection during induction is the major component associated to mortality.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2015.07.007