A systematic review and meta‐regression analysis of prophylactic gabapentin for postoperative pain

Summary We searched MEDLINE, Embase, CINAHL, AMED and CENTRAL databases until December 2014 and included 133 randomised controlled trials of peri‐operative gabapentin vs placebo. Gabapentin reduced mean (95% CI) 24‐h morphine‐equivalent consumption by 8.44 (7.26–9.62) mg, p

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Veröffentlicht in:	Anaesthesia 2015-10, Vol.70 (10), p.1186-1204
Hauptverfasser:	Doleman, B., Heinink, T. P., Read, D. J., Faleiro, R. J., Lund, J. N., Williams, J. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - administration & dosage Amines - adverse effects Analgesics - administration & dosage Analgesics - adverse effects Analgesics, Opioid - administration & dosage Anesthesia Cyclohexanecarboxylic Acids - administration & dosage Cyclohexanecarboxylic Acids - adverse effects Drug Administration Schedule Drug Therapy, Combination gamma-Aminobutyric Acid - administration & dosage gamma-Aminobutyric Acid - adverse effects Humans Meta-analysis Morphine - administration & dosage Pain management Pain, Postoperative - prevention & control Postoperative Nausea and Vomiting - prevention & control Postoperative period Pruritus - prevention & control Systematic review
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Zusammenfassung:	Summary We searched MEDLINE, Embase, CINAHL, AMED and CENTRAL databases until December 2014 and included 133 randomised controlled trials of peri‐operative gabapentin vs placebo. Gabapentin reduced mean (95% CI) 24‐h morphine‐equivalent consumption by 8.44 (7.26–9.62) mg, p
ISSN:	0003-2409 1365-2044
DOI:	10.1111/anae.13179