Meroditerpenoids from a formosan soft coral Nephthea chabrolii

Eight new meroditerpenoid-related metabolites, including one naphthoquinone derivative, chabrolonaphthoquinone B (1), four tetraprenyltoluquinone-related compounds, chabrolobenzoquinones E-H (2-5), and three tetraprenyltoluquinol-related metabolites, chabrolohydroxybenzoquinones E-G (6-8), were isol...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2005-11, Vol.68 (11), p.1651-1655
Hauptverfasser: Su, J.H, Ahmed, A.F, Sung, P.J, Wu, Y.C, Sheu, J.H
Format: Artikel
Sprache:eng
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Zusammenfassung:Eight new meroditerpenoid-related metabolites, including one naphthoquinone derivative, chabrolonaphthoquinone B (1), four tetraprenyltoluquinone-related compounds, chabrolobenzoquinones E-H (2-5), and three tetraprenyltoluquinol-related metabolites, chabrolohydroxybenzoquinones E-G (6-8), were isolated from the organic extract of a Taiwanese soft coral Nephthea chabrolii. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of the related metabolites. Cytotoxic activity of metabolites 1-3 and 5-8 against a limited panel of cancer cell lines is also described.
ISSN:0163-3864
1520-6025
DOI:10.1021/np050278a