Particulate Matter Initiates Inflammatory Cytokine Release by Activation of Capsaicin and Acid Receptors in a Human Bronchial Epithelial Cell Line

Recent experiments have shown that human bronchial epithelial cells (i.e., BEAS-2B) release pro-inflammatory cytokines (i.e., IL-6 and TNFα) in a receptor-mediated fashion in response to the neuropeptides, substance P (SP), calcitonin gene-related protein (CGRP), and the prototype botanical irritant...

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Veröffentlicht in:	Toxicology and applied pharmacology 1999-01, Vol.154 (1), p.106-115
Hauptverfasser:	Veronesi, B., Oortgiesen, M., Carter, J.D., Devlin, R.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	acid sensitive pH receptor acidic particulates Air Air Pollutants Amiloride - pharmacology BEAS-2B Biological and medical sciences Bronchi - secretion bronchial epithelial cells Calcitonin Gene-Related Peptide - pharmacology Calcium - metabolism Capsaicin - metabolism capsaicin receptor Carbon - pharmacology Cell Line Coal Ash Cytokines - secretion Environmental pollutants toxicology Epithelium - secretion Humans Hydrogen-Ion Concentration Interleukin-6 - secretion Interleukin-8 - secretion irritant receptors Medical sciences neurogenic inflammation Neurokinin-1 Receptor Antagonists neuropeptides Particulate Matter Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors Receptors, Calcitonin Gene-Related Peptide - physiology Receptors, Drug - antagonists & inhibitors Receptors, Drug - physiology Receptors, Neurokinin-1 - physiology residual oil fly ash Substance P - pharmacology Toxicology Tumor Necrosis Factor-alpha - secretion
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