Particulate Matter Initiates Inflammatory Cytokine Release by Activation of Capsaicin and Acid Receptors in a Human Bronchial Epithelial Cell Line

Particulate Matter Initiates Inflammatory Cytokine Release by Activation of Capsaicin and Acid Receptors in a Human Bronchial Epithelial Cell Line

Recent experiments have shown that human bronchial epithelial cells (i.e., BEAS-2B) release pro-inflammatory cytokines (i.e., IL-6 and TNFα) in a receptor-mediated fashion in response to the neuropeptides, substance P (SP), calcitonin gene-related protein (CGRP), and the prototype botanical irritant...

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Veröffentlicht in:Toxicology and applied pharmacology 1999-01, Vol.154 (1), p.106-115
Hauptverfasser: Veronesi, B., Oortgiesen, M., Carter, J.D., Devlin, R.B.
Format: Artikel
Sprache:eng
Schlagworte:
acid sensitive pH receptor
acidic particulates
Air
Air Pollutants
Amiloride - pharmacology
BEAS-2B
Biological and medical sciences
Bronchi - secretion
bronchial epithelial cells
Calcitonin Gene-Related Peptide - pharmacology
Calcium - metabolism
Capsaicin - metabolism
capsaicin receptor
Carbon - pharmacology
Cell Line
Coal Ash
Cytokines - secretion
Environmental pollutants toxicology
Epithelium - secretion
Humans
Hydrogen-Ion Concentration
Interleukin-6 - secretion
Interleukin-8 - secretion
irritant receptors
Medical sciences
neurogenic inflammation
Neurokinin-1 Receptor Antagonists
neuropeptides
Particulate Matter
Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors
Receptors, Calcitonin Gene-Related Peptide - physiology
Receptors, Drug - antagonists & inhibitors
Receptors, Drug - physiology
Receptors, Neurokinin-1 - physiology
residual oil fly ash
Substance P - pharmacology
Toxicology
Tumor Necrosis Factor-alpha - secretion
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Zusammenfassung:Recent experiments have shown that human bronchial epithelial cells (i.e., BEAS-2B) release pro-inflammatory cytokines (i.e., IL-6 and TNFα) in a receptor-mediated fashion in response to the neuropeptides, substance P (SP), calcitonin gene-related protein (CGRP), and the prototype botanical irritant capsaicin. In the present experiments, we examined the relevance of these receptors to particulate matter (PM)-associated cellular inflammation. BEAS-2B cells, exposed to residual oil fly ash particles (ROFA), responded with an immediate (
ISSN:0041-008X
1096-0333
DOI:10.1006/taap.1998.8567