Arg-Gly-Asp-Ser (RGDS) peptide stimulates transforming growth factor beta 1 transcription and secretion through integrin activation
Through specific peptide motifs such as RGD (ARG-GLY-ASP), extracellular matrix (ECM) components interact with integrin and can modify the behavior of cells. We analyzed the effect of an RGD-containing peptide, RGDS, on the regulation of TGF- beta 1 secretion by cultured human mesangial cells (HMC)...
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Veröffentlicht in: | The FASEB journal 2003-08, Vol.17 (11), p.1529-1531 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | Through specific peptide motifs such as RGD (ARG-GLY-ASP), extracellular matrix (ECM) components interact with integrin and can modify the behavior of cells. We analyzed the effect of an RGD-containing peptide, RGDS, on the regulation of TGF- beta 1 secretion by cultured human mesangial cells (HMC) and the intracellular mechanisms implied in signal transduction. |
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ISSN: | 0892-6638 |
DOI: | 10.1096/fj.02-0785fje |