Arg-Gly-Asp-Ser (RGDS) peptide stimulates transforming growth factor beta 1 transcription and secretion through integrin activation

Through specific peptide motifs such as RGD (ARG-GLY-ASP), extracellular matrix (ECM) components interact with integrin and can modify the behavior of cells. We analyzed the effect of an RGD-containing peptide, RGDS, on the regulation of TGF- beta 1 secretion by cultured human mesangial cells (HMC)...

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Veröffentlicht in:The FASEB journal 2003-08, Vol.17 (11), p.1529-1531
Hauptverfasser: Ortega-Velazquez, R, Diez-Marques, M L, Ruiz-Torres, M P, Gonzalez-Rubio, M, Rodriguez-Puyol, M, Puyol, DRodriguez
Format: Artikel
Sprache:eng
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Zusammenfassung:Through specific peptide motifs such as RGD (ARG-GLY-ASP), extracellular matrix (ECM) components interact with integrin and can modify the behavior of cells. We analyzed the effect of an RGD-containing peptide, RGDS, on the regulation of TGF- beta 1 secretion by cultured human mesangial cells (HMC) and the intracellular mechanisms implied in signal transduction.
ISSN:0892-6638
DOI:10.1096/fj.02-0785fje