Spatial memory impairment in ventral subicular lesioned rats

The present study examined the effects of ibotenic acid lesions of the ventral subiculum (SUB) on the ability of rats to memorize a rewarded alternation test in a T-maze. Results indicated that rats with ibotenic acid lesions (IL) of the ventral subiculum were impaired in postoperative acquisition o...

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Veröffentlicht in:	Brain research 1999-01, Vol.816 (1), p.245-248
Hauptverfasser:	Laxmi, T.R., Bindu, P.N., Raju, T.R., Meti, B.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomical correlates of behavior Animals Behavior, Animal - physiology Behavioral psychophysiology Biological and medical sciences Conditioning, Operant - physiology Fundamental and applied biological sciences. Psychology Hippocampus - physiology Ibotenic acid Ibotenic Acid - administration & dosage Male Maze Learning - physiology Memory - physiology Memory Disorders - chemically induced Microinjections Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Retention (Psychology) - physiology Rewarded alternation task Spatial Behavior - physiology T-maze Ventral subiculum Wakefulness
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Zusammenfassung:	The present study examined the effects of ibotenic acid lesions of the ventral subiculum (SUB) on the ability of rats to memorize a rewarded alternation test in a T-maze. Results indicated that rats with ibotenic acid lesions (IL) of the ventral subiculum were impaired in postoperative acquisition of the spatial discrimination task, making more errors than the vehicle treated and normal control rats. In addition, all rats, including the IL group of rats, were able to memorize an acquired spatial behaviour. These findings suggest that the SUB play an important role in spatial information processing in rats.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(98)01187-1