Diagnostic accuracy of pace spikes in the electrocardiogram to diagnose paced rhythm

Abstract Objective To determine how often cardiac resynchronization therapy (CRT) pacing systems generate visible pace spikes in the electrocardiogram (ECG). Methods In 46 patients treated with CRT pacing systems, we recorded ECGs during intrinsic rhythm, atrial pacing and ventricular pacing. ECGs were analysed for atrial and ventricular pace spikes by two experienced ECG readers blinded to the pacing therapy and to the study purpose. Results Atrial pacing generated visible pace spikes in less than 70% of the ECGs, whereas ventricular pacing generated visible pace spikes in about 90% of ECGs. The sensitivity of manual ECG interpretation for pace spikes was low for atrial pacing (Reader 1: 0.62 [95% confidence interval (CI) 0.50–0.74]; Reader 2: 0.65 [95% CI 0.53–0.77]) and moderate for ventricular pacing (Reader 1: 0.88 [95% CI 0.81–0.93]; Reader 2: 0.93 [95% CI 0.87–0.97]). Conclusions In patients with CRT pacing systems, the absence of visible pace spikes in the ECG does not rule out paced rhythm.