Inhibitory effects of Cordia spinescens extracts and their constituents on reverse transcriptase and protease from human immunodeficiency virus

By bioactive‐guided fractionation of a water extract of Cordia spinescens, magnesium lithospermate (1), calcium rosmarinate (2) and magnesium rosmarinate (3) were isolated as potent inhibitory substances against HIV‐1 reverse transcriptase (RT) with IC50 values of 0.8, 5.8 and 3.1 μM, respectively....

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Veröffentlicht in:	Phytotherapy research 1997-11, Vol.11 (7), p.490-495
Hauptverfasser:	Lim, Yasmina Aura, Kojima, Shiho, Nakamura, Norio, Miyashiro, Hirotsugu, Fushimi, Hirotoshi, Komatsu, Katsuko, Hattori, Masao, Shimotohno, Kunitada, Gupta, Mahabir P., Correa, Mireya
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Boraginaceae calcium rosmarinate Cordia spinescens General pharmacology HIV-1 Human immunodeficiency virus magnesium lithospermate magnesium rosmarinate Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments protease reverse transcriptase
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Zusammenfassung:	By bioactive‐guided fractionation of a water extract of Cordia spinescens, magnesium lithospermate (1), calcium rosmarinate (2) and magnesium rosmarinate (3) were isolated as potent inhibitory substances against HIV‐1 reverse transcriptase (RT) with IC50 values of 0.8, 5.8 and 3.1 μM, respectively. However, they were weak HIV‐1 protease (PR) inhibitors with IC50>100 μM. The RT inhibition by these compounds was noncompetitive with respect to dTTP substrate. © 1997 John Wiley & Sons, Ltd.
ISSN:	0951-418X 1099-1573
DOI:	10.1002/(SICI)1099-1573(199711)11:7<490::AID-PTR134>3.0.CO;2-Y