Chemotherapy for Surgically Resected Intrahepatic Cholangiocarcinoma

Background The benefit of chemotherapy for surgically resected intrahepatic cholangiocarcinoma (ICC) remains poorly defined. The present study sought to determine the survival impact of chemotherapy for surgically resected ICC. Methods Patients with non-metastatic ICC who underwent surgery were iden...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of surgical oncology 2015-10, Vol.22 (11), p.3716-3723
Hauptverfasser:	Miura, John T., Johnston, Fabian M., Tsai, Susan, George, Ben, Thomas, Jim, Eastwood, Dan, Banerjee, Anjishnu, Christians, Kathleen K., Turaga, Kiran K., Pawlik, Timothy M., Clark Gamblin, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents - therapeutic use Bile Duct Neoplasms - drug therapy Bile Duct Neoplasms - pathology Bile Duct Neoplasms - surgery Bile Ducts, Intrahepatic Chemotherapy, Adjuvant Cholangiocarcinoma - drug therapy Cholangiocarcinoma - secondary Cholangiocarcinoma - surgery Female Hepatobiliary Tumors Humans Lymphatic Metastasis Male Medicine Medicine & Public Health Middle Aged Neoplasm Grading Neoplasm Staging Neoplasm, Residual Oncology Surgery Surgical Oncology Survival Rate
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background The benefit of chemotherapy for surgically resected intrahepatic cholangiocarcinoma (ICC) remains poorly defined. The present study sought to determine the survival impact of chemotherapy for surgically resected ICC. Methods Patients with non-metastatic ICC who underwent surgery were identified from the National Cancer Database (1998–2011) and stratified by receipt of chemotherapy. Survival outcomes were analyzed following propensity score modeling using the greedy matching algorithm. Results A total of 2751 patients were identified (median age 64 years); 985 (35.8 %) received chemotherapy. Younger age, advanced tumor stage, R1/R2 surgical margins, and lymph node metastasis were all independently associated with receipt of chemotherapy ( p
ISSN:	1068-9265 1534-4681
DOI:	10.1245/s10434-015-4501-8