Releasing the Brakes on Cancer Immunotherapy

This year’s Lasker∼DeBakey Clinical Research Award goes to James Allison for discovering that antibody blockade of the T cell molecule CTLA-4 unleashes the body’s immune response against malignant tumors. This has led to development of multiple “immune checkpoint therapies” that are prolonging and s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2015-09, Vol.162 (6), p.1186-1190
1. Verfasser:	Littman, Dan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allison Animals Awards and Prizes CTLA-4 Antigen History, 20th Century History, 21st Century Humans Immunotherapy - history Molecular Targeted Therapy Neoplasms - immunology Neoplasms - therapy T-Lymphocytes - immunology United States
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	This year’s Lasker∼DeBakey Clinical Research Award goes to James Allison for discovering that antibody blockade of the T cell molecule CTLA-4 unleashes the body’s immune response against malignant tumors. This has led to development of multiple “immune checkpoint therapies” that are prolonging and saving the lives of thousands of cancer patients. This year’s Lasker∼DeBakey Clinical Research Award goes to James Allison for discovering that antibody blockade of the T cell molecule CTLA-4 unleashes the body’s immune response against malignant tumors. This has led to development of multiple “immune checkpoint therapies” that are prolonging and saving the lives of thousands of cancer patients.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2015.08.038