Serum cystatin C and chitotriosidase in acute P-407 induced dyslipidemia: Can they serve as potential early biomarkers for atherosclerosis?

In an attempt to better understand potential biomarkers for, and the role of macrophages in, the development of atherosclerosis, the toxicologic, and any therapeutic pharmacologic effects of carboxymethylated β-glucan, gadolinium chloride, and poloxamer 407 were studied in mice for their capacity to...

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Veröffentlicht in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2015-09, Vol.67 (9), p.459-466
Hauptverfasser:	Korolenko, T.A., Pisareva, E.E., Filyushina, E.E., Johnston, T.P., Machova, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis - blood Atherosclerosis - diagnosis Atherosclerosis - enzymology Beta-glucan Biomarkers Biomarkers - blood Chitotriosidase Cystatin C Cystatin C - blood Disease Models, Animal Dyslipidemia Dyslipidemias - blood Dyslipidemias - chemically induced Dyslipidemias - enzymology Early Diagnosis Hexosaminidases - blood Lipids - blood Liver - drug effects Liver - pathology Macrophages Male Mice, Inbred CBA Poloxamer - toxicity
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Zusammenfassung:	In an attempt to better understand potential biomarkers for, and the role of macrophages in, the development of atherosclerosis, the toxicologic, and any therapeutic pharmacologic effects of carboxymethylated β-glucan, gadolinium chloride, and poloxamer 407 were studied in mice for their capacity to perturb serum lipids, cystatin C, and chitotriosidase-1. Gadolinium and carboxymethylated β-glucan dosed separately to control mice had no effect on serum lipids, whereas carboxymethylated β-glucan, but not gadolinium, exerted a significant (p
ISSN:	0940-2993 1618-1433
DOI:	10.1016/j.etp.2015.06.003