Risk Factors for Recurrence of Periprosthetic Knee Infection

Abstract We retrospectively reviewed 110 patients who underwent two-stage revision surgery in order to identify potential risk factors for recurrence of periprosthetic infection. We found that patients with inflammatory arthritis ( P = 0.0125), perioperative hematoma formation ( P = 0.0422), wound dehiscence ( P = 0.042), and those who are chronic Staphylococcus carriers ( P = 0.0177) were associated with an increased incidence of re-infection. The duration of intravenous antibiotic therapy less than 6 weeks was associated with a reduced risk of reinfection to greater than 6 weeks ( P = 0.03). Multivariate analysis indicated that wound dehiscence (odds ratio [OR], 5.119; 95% confidence interval [CI], 1.367–19.17), and Staphylococcus carriers (OR, 11.419; 95% CI, 1.376–94.727) are significant predictors of recurrence ( P = 0.0153 and 0.0241, respectively).