Mycophenolate mofetil-induced villous atrophy
Mycophenolate mofetil (MMF) is a new immunosuppressant developed for the prevention and treatment of acute renal rejection after transplantation. Diarrhea is the most frequent side effect observed during treatment with MMF. Its pathogenic mechanisms remain unknown. We describe a case of severe diarr...
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| Veröffentlicht in: | Transplantation 1998-10, Vol.66 (8), p.1115-1116 |
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| container_end_page | 1116 |
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| container_issue | 8 |
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| container_title | Transplantation |
| container_volume | 66 |
| creator | DUCLOUX, D OTTIGNON, Y SEMHOUN-DUCLOUX, S LABBE, S SAINT-HILLIER, Y MIGUET, J.-P CARAYON, P CHALOPIN, J.-M |
| description | Mycophenolate mofetil (MMF) is a new immunosuppressant developed for the prevention and treatment of acute renal rejection after transplantation. Diarrhea is the most frequent side effect observed during treatment with MMF. Its pathogenic mechanisms remain unknown. We describe a case of severe diarrhea due to villous atrophy in a renal transplant recipient during treatment with MMF. The patient was free of symptoms before MMF. Villous atrophy disappeared a few months after MMF withdrawal. |
| doi_str_mv | 10.1097/00007890-199810270-00027 |
| format | Article |
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Diarrhea is the most frequent side effect observed during treatment with MMF. Its pathogenic mechanisms remain unknown. We describe a case of severe diarrhea due to villous atrophy in a renal transplant recipient during treatment with MMF. The patient was free of symptoms before MMF. Villous atrophy disappeared a few months after MMF withdrawal.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-199810270-00027</identifier><identifier>PMID: 9808503</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Atrophy ; Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; Immunosuppressive Agents - administration & dosage ; Intestine, Small - drug effects ; Intestine, Small - pathology ; Kidney Transplantation ; Medical sciences ; Microvilli - drug effects ; Microvilli - pathology ; Mycophenolic Acid - adverse effects ; Mycophenolic Acid - analogs & derivatives ; Pharmacology. 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Diarrhea is the most frequent side effect observed during treatment with MMF. Its pathogenic mechanisms remain unknown. We describe a case of severe diarrhea due to villous atrophy in a renal transplant recipient during treatment with MMF. The patient was free of symptoms before MMF. Villous atrophy disappeared a few months after MMF withdrawal.</description><subject>Adult</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Intestine, Small - drug effects</subject><subject>Intestine, Small - pathology</subject><subject>Kidney Transplantation</subject><subject>Medical sciences</subject><subject>Microvilli - drug effects</subject><subject>Microvilli - pathology</subject><subject>Mycophenolic Acid - adverse effects</subject><subject>Mycophenolic Acid - analogs & derivatives</subject><subject>Pharmacology. Drug treatments</subject><subject>Toxicity: digestive system</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE9PwzAMxSMEGmPwEZB6QNwCdrI2yRFN_JOGuMA5ShNXFHXtaFqkfXsCK-CLJfs9P-vHWIZwhWDUNaRS2gBHYzSCUMDTRKgDNsdcLnkBGg7ZHGCJHKVUx-wkxvckyaVSMzYzGnQOcs7408532zdqu8YNlG26ioa64XUbRk8h-6ybphtj5oY-qXan7KhyTaSzqS_Y693ty-qBr5_vH1c3a-6XAgZOZVWYUoIqVQqigJQbygsn028lhsqogK70oUAvgiMQFWktSRgDeZEGcsEu93e3ffcxUhzspo6emsa1lN6xqBCFkJiEei_0fRdjT5Xd9vXG9TuLYL9J2V9S9o-U_SGVrOdTxlhuKPwZJzRpfzHtXfSuqXrX-jr-38-NkFrJL2_-cHo</recordid><startdate>19981027</startdate><enddate>19981027</enddate><creator>DUCLOUX, D</creator><creator>OTTIGNON, Y</creator><creator>SEMHOUN-DUCLOUX, S</creator><creator>LABBE, S</creator><creator>SAINT-HILLIER, Y</creator><creator>MIGUET, J.-P</creator><creator>CARAYON, P</creator><creator>CHALOPIN, J.-M</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19981027</creationdate><title>Mycophenolate mofetil-induced villous atrophy</title><author>DUCLOUX, D ; OTTIGNON, Y ; SEMHOUN-DUCLOUX, S ; LABBE, S ; SAINT-HILLIER, Y ; MIGUET, J.-P ; CARAYON, P ; CHALOPIN, J.-M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-ebf69b307b7980ed1e59e56a3153b1df97d1abcd61c2dae02fe883e299056dae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Humans</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Intestine, Small - drug effects</topic><topic>Intestine, Small - pathology</topic><topic>Kidney Transplantation</topic><topic>Medical sciences</topic><topic>Microvilli - drug effects</topic><topic>Microvilli - pathology</topic><topic>Mycophenolic Acid - adverse effects</topic><topic>Mycophenolic Acid - analogs & derivatives</topic><topic>Pharmacology. Drug treatments</topic><topic>Toxicity: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DUCLOUX, D</creatorcontrib><creatorcontrib>OTTIGNON, Y</creatorcontrib><creatorcontrib>SEMHOUN-DUCLOUX, S</creatorcontrib><creatorcontrib>LABBE, S</creatorcontrib><creatorcontrib>SAINT-HILLIER, Y</creatorcontrib><creatorcontrib>MIGUET, J.-P</creatorcontrib><creatorcontrib>CARAYON, P</creatorcontrib><creatorcontrib>CHALOPIN, J.-M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DUCLOUX, D</au><au>OTTIGNON, Y</au><au>SEMHOUN-DUCLOUX, S</au><au>LABBE, S</au><au>SAINT-HILLIER, Y</au><au>MIGUET, J.-P</au><au>CARAYON, P</au><au>CHALOPIN, J.-M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mycophenolate mofetil-induced villous atrophy</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1998-10-27</date><risdate>1998</risdate><volume>66</volume><issue>8</issue><spage>1115</spage><epage>1116</epage><pages>1115-1116</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Mycophenolate mofetil (MMF) is a new immunosuppressant developed for the prevention and treatment of acute renal rejection after transplantation. Diarrhea is the most frequent side effect observed during treatment with MMF. Its pathogenic mechanisms remain unknown. We describe a case of severe diarrhea due to villous atrophy in a renal transplant recipient during treatment with MMF. The patient was free of symptoms before MMF. Villous atrophy disappeared a few months after MMF withdrawal.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>9808503</pmid><doi>10.1097/00007890-199810270-00027</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 1998-10, Vol.66 (8), p.1115-1116 |
| issn | 0041-1337 1534-6080 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Atrophy Biological and medical sciences Drug toxicity and drugs side effects treatment Female Humans Immunosuppressive Agents - administration & dosage Intestine, Small - drug effects Intestine, Small - pathology Kidney Transplantation Medical sciences Microvilli - drug effects Microvilli - pathology Mycophenolic Acid - adverse effects Mycophenolic Acid - analogs & derivatives Pharmacology. Drug treatments Toxicity: digestive system |
| title | Mycophenolate mofetil-induced villous atrophy |
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