Mycophenolate mofetil-induced villous atrophy

Mycophenolate mofetil-induced villous atrophy

Mycophenolate mofetil (MMF) is a new immunosuppressant developed for the prevention and treatment of acute renal rejection after transplantation. Diarrhea is the most frequent side effect observed during treatment with MMF. Its pathogenic mechanisms remain unknown. We describe a case of severe diarr...

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Veröffentlicht in:Transplantation 1998-10, Vol.66 (8), p.1115-1116
Hauptverfasser: DUCLOUX, D, OTTIGNON, Y, SEMHOUN-DUCLOUX, S, LABBE, S, SAINT-HILLIER, Y, MIGUET, J.-P, CARAYON, P, CHALOPIN, J.-M
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Atrophy
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Female
Humans
Immunosuppressive Agents - administration & dosage
Intestine, Small - drug effects
Intestine, Small - pathology
Kidney Transplantation
Medical sciences
Microvilli - drug effects
Microvilli - pathology
Mycophenolic Acid - adverse effects
Mycophenolic Acid - analogs & derivatives
Pharmacology. Drug treatments
Toxicity: digestive system
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Zusammenfassung:Mycophenolate mofetil (MMF) is a new immunosuppressant developed for the prevention and treatment of acute renal rejection after transplantation. Diarrhea is the most frequent side effect observed during treatment with MMF. Its pathogenic mechanisms remain unknown. We describe a case of severe diarrhea due to villous atrophy in a renal transplant recipient during treatment with MMF. The patient was free of symptoms before MMF. Villous atrophy disappeared a few months after MMF withdrawal.
ISSN:0041-1337
1534-6080
DOI:10.1097/00007890-199810270-00027