Effect of permeabilizing agents on antibacterial activity against a simple Pseudomonas aeruginosa biofilm

A simple Pseudomonas aeruginosa G48 biofilm on stainless steel discs provided a useful primary screen of the potentiating effects of various permeabilizing agents on antibacterial agents. Experiments with Ps. aeruginosa suspensions could not be used to predict the effects of biocides and permeabiliz...

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Veröffentlicht in:	Letters in applied microbiology 1998-08, Vol.27 (2), p.79-82
Hauptverfasser:	Ayres, H.M., Payne, D.N., Furr, J.R., Russell, A.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action of physical and chemical agents on bacteria Anti-Infective Agents, Local - pharmacology Bacteriology Biofilms - drug effects Biofilms - growth & development Biological and medical sciences Cell Membrane Permeability - drug effects Drug Synergism Edetic Acid - pharmacology Fundamental and applied biological sciences. Psychology Microbiology Polyphosphates - pharmacology Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - growth & development
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Beschreibung
Zusammenfassung:	A simple Pseudomonas aeruginosa G48 biofilm on stainless steel discs provided a useful primary screen of the potentiating effects of various permeabilizing agents on antibacterial agents. Experiments with Ps. aeruginosa suspensions could not be used to predict the effects of biocides and permeabilizers on biofilms. Although antibacterial activity against biofilms was less than demonstrated in suspension tests, potentiation by some permeabilizers was still observed.
ISSN:	0266-8254 1472-765X 1365-2673
DOI:	10.1046/j.1472-765X.1998.00397.x