Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED)
Highlights • We demonstrated the feasibility of low-fluence rate and long duration OLED-PDT in glioma mouse model. • Tumor severity shows statistically significant correlation with survival days. • mPDT in glioma mouse model is promising with a longer survival time. • Maintenance of photosensitizer...
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Veröffentlicht in: | Photodiagnosis and photodynamic therapy 2015-09, Vol.12 (3), p.504-510 |
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container_title | Photodiagnosis and photodynamic therapy |
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creator | Guo, Han-Wen Lin, Liang-Ting Chen, Po-Hsiung Ho, Meng-Huan Huang, Wan-Ting Lee, Yi-Jang Chiou, Shih-Hwa Hsieh, Yei-San Dong, Chen-Yuan Wang, Hsing-Wen |
description | Highlights • We demonstrated the feasibility of low-fluence rate and long duration OLED-PDT in glioma mouse model. • Tumor severity shows statistically significant correlation with survival days. • mPDT in glioma mouse model is promising with a longer survival time. • Maintenance of photosensitizer fluorescence and oxygenation is critical for PDT. |
doi_str_mv | 10.1016/j.pdpdt.2015.04.007 |
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Lin, Liang-Ting ; Chen, Po-Hsiung ; Ho, Meng-Huan ; Huang, Wan-Ting ; Lee, Yi-Jang ; Chiou, Shih-Hwa ; Hsieh, Yei-San ; Dong, Chen-Yuan ; Wang, Hsing-Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-573bc8ef542c50e9f9651faf191cb63ce92654c16c55d8a2512d4c2a2ae344fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>5-Aminolevulinic acid (ALA)</topic><topic>Aminolevulinic Acid - pharmacology</topic><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Glioblastoma - drug therapy</topic><topic>Gliomas</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Metronomic photodynamic therapy (mPDT)</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Organic light emitting diode (OLED)</topic><topic>Photochemotherapy - methods</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Pilot Projects</topic><topic>Protoporphyrins</topic><topic>Survival Analysis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Han-Wen</creatorcontrib><creatorcontrib>Lin, Liang-Ting</creatorcontrib><creatorcontrib>Chen, Po-Hsiung</creatorcontrib><creatorcontrib>Ho, Meng-Huan</creatorcontrib><creatorcontrib>Huang, Wan-Ting</creatorcontrib><creatorcontrib>Lee, Yi-Jang</creatorcontrib><creatorcontrib>Chiou, Shih-Hwa</creatorcontrib><creatorcontrib>Hsieh, Yei-San</creatorcontrib><creatorcontrib>Dong, Chen-Yuan</creatorcontrib><creatorcontrib>Wang, Hsing-Wen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Photodiagnosis and photodynamic therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Han-Wen</au><au>Lin, Liang-Ting</au><au>Chen, Po-Hsiung</au><au>Ho, Meng-Huan</au><au>Huang, Wan-Ting</au><au>Lee, Yi-Jang</au><au>Chiou, Shih-Hwa</au><au>Hsieh, Yei-San</au><au>Dong, Chen-Yuan</au><au>Wang, Hsing-Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED)</atitle><jtitle>Photodiagnosis and photodynamic therapy</jtitle><addtitle>Photodiagnosis Photodyn Ther</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>12</volume><issue>3</issue><spage>504</spage><epage>510</epage><pages>504-510</pages><issn>1572-1000</issn><eissn>1873-1597</eissn><abstract>Highlights • We demonstrated the feasibility of low-fluence rate and long duration OLED-PDT in glioma mouse model. • Tumor severity shows statistically significant correlation with survival days. • mPDT in glioma mouse model is promising with a longer survival time. • Maintenance of photosensitizer fluorescence and oxygenation is critical for PDT.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25936596</pmid><doi>10.1016/j.pdpdt.2015.04.007</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0878-8205</orcidid></addata></record> |
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subjects | 5-Aminolevulinic acid (ALA) Aminolevulinic Acid - pharmacology Animals Disease Models, Animal Glioblastoma - drug therapy Gliomas Hematology, Oncology and Palliative Medicine Humans Internal Medicine Metronomic photodynamic therapy (mPDT) Mice Mice, Nude Organic light emitting diode (OLED) Photochemotherapy - methods Photosensitizing Agents - pharmacology Pilot Projects Protoporphyrins Survival Analysis Time Factors |
title | Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED) |
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