Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED)

Highlights • We demonstrated the feasibility of low-fluence rate and long duration OLED-PDT in glioma mouse model. • Tumor severity shows statistically significant correlation with survival days. • mPDT in glioma mouse model is promising with a longer survival time. • Maintenance of photosensitizer...

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Veröffentlicht in:	Photodiagnosis and photodynamic therapy 2015-09, Vol.12 (3), p.504-510
Hauptverfasser:	Guo, Han-Wen, Lin, Liang-Ting, Chen, Po-Hsiung, Ho, Meng-Huan, Huang, Wan-Ting, Lee, Yi-Jang, Chiou, Shih-Hwa, Hsieh, Yei-San, Dong, Chen-Yuan, Wang, Hsing-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Aminolevulinic acid (ALA) Aminolevulinic Acid - pharmacology Animals Disease Models, Animal Glioblastoma - drug therapy Gliomas Hematology, Oncology and Palliative Medicine Humans Internal Medicine Metronomic photodynamic therapy (mPDT) Mice Mice, Nude Organic light emitting diode (OLED) Photochemotherapy - methods Photosensitizing Agents - pharmacology Pilot Projects Protoporphyrins Survival Analysis Time Factors
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Zusammenfassung:	Highlights • We demonstrated the feasibility of low-fluence rate and long duration OLED-PDT in glioma mouse model. • Tumor severity shows statistically significant correlation with survival days. • mPDT in glioma mouse model is promising with a longer survival time. • Maintenance of photosensitizer fluorescence and oxygenation is critical for PDT.
ISSN:	1572-1000 1873-1597
DOI:	10.1016/j.pdpdt.2015.04.007