Risks of peripheral arterial occlusive disease in patients with obstructive sleep apnoea: a population-based case-control study

Objectives This study aimed to evaluate the risk of peripheral arterial occlusive disease (PAOD) in patients with obstructive sleep apnoea (OSA) using a nationwide claim database in Taiwan. Design A population‐based case–control study. Setting Data from the Longitudinal Health Insurance Database 2000 of the Taiwan's National Health Insurance Research Database. Participants Eleven thousand eight hundred and seventeen adult patients diagnosed with PAOD between January 1, 2001 and December 31, 2010 and 35 451 controls without PAOD frequency matched by sex, 10‐year age interval and year of index date. Main outcome measures Obstructive sleep apnoea and a number of comorbidities prior to the index date were assessed and analysed with logistic regression analyses. Results Univariate logistic regression analysis showed that PAOD was significantly associated with OSA (odds ratio, OR = 1.60, P