Total introduction of microsamples in inductively coupled plasma mass spectrometry by high-temperature evaporation chamber with a sheathing gas stream

[Display omitted] ► The main features of high-temperature TISIS for use in ICP-MS have been evaluated. ► The sensitivity was 2–8 times higher than that measured for conventional systems. ► Limits of detection were lower for many elements. ► The system was applied to environmental, biological and clinical micro-samples. A systematic study on the high-temperature Torch Integrated Sample Introduction System (TISIS) for use in Inductively Coupled Plasma Mass Spectrometry (ICP-MS) has been performed. The investigation included the optimization of the relevant parameters (chamber temperature, sheathing gas flow rate, nebulizer gas flow rate, sample uptake rate), the evaluation of its performance characteristics (sensitivity, limits of detection, stability, memory effects, use with the dynamic reaction cell) and representative applications to environmental, biological and clinical samples. Under the optimal conditions (T=150°C; nebulizer gas flow rate of 0.7Lmin−1 along with sheathing gas flow rate of 0.35Lmin−1 and a sample uptake rate of 20μLmin−1), the sensitivity was from 2 to 8 times higher than that measured using a conventional micronebulizer/mini-spray chamber system, due to the enhanced analyte mass transport toward the plasma and the solvent introduction in the vapour form. In addition, for several elements, TISIS provided lower limits of detection than the conventional system, even when the latter worked at 5-fold higher sample uptake rate. Short-term and long-term precision was better than 5%. Spectroscopic interferences arising from common matrices were efficiently removed by the dynamic reaction cell technique. The application of TISIS/ICP-MS to representative certified reference samples (spinach leaves, marine plankton, bone tissue, human blood) proved the suitability of this system for the accurate analysis of limited-size samples.