Pheomelanin-coated iron oxide magnetic nanoparticles: a promising candidate for negative T sub(2) contrast enhancement in magnetic resonance imaging

Pheomelanin-coated iron oxide magnetic nanoparticles: a promising candidate for negative T sub(2) contrast enhancement in magnetic resonance imaging

We describe herein a novel type of monodisperse water-soluble magnetite nanoparticle coated with pheomelanin using an environmentally-friendly approach in aqueous medium. The results indicate superparamagnetic behaviour at room temperature and show improved negative contrast in T sub(2)-weighted MRI...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-06, Vol.51 (56), p.11194-11197
Hauptverfasser: Zottis, Alexandre DA, Beltrame, Jeovandro M, Lara, Luciano RS, Costa, Thiago G, Feldhaus, Mateus J, Pedrosa, Rozangela Curi, Ourique, Fabiana, de Campos, Carlos EM, Isoppo, Eduardo de A, da Silva Miranda, Fabio, Szpoganicz, Bruno
Format: Artikel
Sprache:eng
Schlagworte:
Coating
Iron oxides
Magnetic resonance imaging
Magnetite
Nanoparticles
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Beschreibung
Zusammenfassung:We describe herein a novel type of monodisperse water-soluble magnetite nanoparticle coated with pheomelanin using an environmentally-friendly approach in aqueous medium. The results indicate superparamagnetic behaviour at room temperature and show improved negative contrast in T sub(2)-weighted MRI with a transverse relaxivity of 218 mM super(-1) s super(-1).
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc02536b