Comparative real-time study of cellular uptake of a formulated conjugated linolenic acid rich nano and conventional macro emulsions and their bioactivity in ex vivo models for parenteral applications

•Colloidal nanotechnology: Fabrication of a stable ESA-NE system.•Nanoparticle uptake: real-time tracking & interpretation.•Corroborative Evidence: metabolic fate of size dependent ESA rich TG formulations.•Fluorescence imaging & cytometric data: role of ESA in countering oxidative stress. T...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2015-02, Vol.126, p.426-436
Hauptverfasser:	Paul, Debjyoti, Mukherjee, Sayani, Chakraborty, Rajarshi, Mallick, Sanjaya K., Dhar, Pubali
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Linolenic Acid - chemistry alpha-Linolenic Acid - pharmacology Cell Death - drug effects Cell Survival - drug effects Cellular Dose-Response Relationship, Drug Effectiveness Emulsions Emulsions - chemistry Emulsions - pharmacology Flow cytometry Humans Leukocytes, Mononuclear - chemistry Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - metabolism Linolenic acid Macromolecular Substances - chemistry Macromolecular Substances - pharmacology Mathematical models Nanoemulsion Nanostructure Nanostructures - chemistry Particle Size Reactive oxygen species Reactive Oxygen Species - metabolism Real time Structure-Activity Relationship Surface Properties Time Factors Transmission electron microscopy Uptakes α-Eleostearic acid
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Zusammenfassung:	•Colloidal nanotechnology: Fabrication of a stable ESA-NE system.•Nanoparticle uptake: real-time tracking & interpretation.•Corroborative Evidence: metabolic fate of size dependent ESA rich TG formulations.•Fluorescence imaging & cytometric data: role of ESA in countering oxidative stress. The objective of the present study was to fabricate and monitor real-time, impact of a stable conjugated linolenic acid, α-eleostearic acid (ESA) rich nanoemulsion (NE) formulation (d
ISSN:	0927-7765 1873-4367
DOI:	10.1016/j.colsurfb.2014.12.046