Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug

Polymers in tune. Automated parallel polymer synthesis is developed to obtain libraries of macromolecular prodrugs of ribavirin, a broad‐spectrum antiviral agent. As many as 10 identified lead polymer conjugates exhibit therapeutic efficacy matching that of the pristine drug and at the same time sup...

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Veröffentlicht in:	Advanced healthcare materials 2014-09, Vol.3 (9), p.1404-1407
Hauptverfasser:	Smith, Anton A. A., Wohl, Benjamin M., Kryger, Mille B. L., Hedemann, Natasha, Guerrero-Sanchez, Carlos, Postma, Almar, Zelikin, Alexander N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Cell Line Chemical compounds Chromatography, Gel Conjugates drug delivery Drug Discovery Drugs Effectiveness Health care high throughput screening inflammation Macrophages - drug effects Macrophages - metabolism Magnetic Resonance Spectroscopy Medical sciences Mice Molecular Weight Nitric Oxide - analysis Nitric Oxide - metabolism Origins Polymers prodrugs Prodrugs - chemistry Prodrugs - pharmacology Ribavirin - chemistry Ribavirin - pharmacology Side effects Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments
Online-Zugang:	Volltext
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